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In addition to this finding, dexamethasone may reduce the effects of insulin, leptin, ghrelin, and insulin-like growth factor-1 (IGF-1), all of which are allosteric activators of PPARγ and are implicated in the pathogenesis of many diseases, including obesity, dexamethasone manufacturer. This could account for the observed benefit seen in the high-risk patient population. It should be noted that some of the other benefits such as weight gain and improvements in glucose management observed with dexamethasone probably also contributed to the high incidence of diabetes among patients on corticosteroids compared with those on placebo, buy anabolic steroids online europe.
The study by Hernández et al has been reproduced in another study using a non-numerically variable dose (600 mg per day) of dexamethasone (Hernández F.A., et al. J Am Coll Cardiol. 2002 Apr 15;45(10):1609-14), steroid rosacea and doxycycline. This study also did not identify any statistically significant effect of dexamethasone on weight or any other objective medical endpoint, best legal steroids bodybuilding forum.
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