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While anabolic steroids were originally purposed to increase muscle mass in patients with muscle wasting diseases, they also have fat-loss effectsfor individuals who wish to gain weight as a result. Anabolic steroids have numerous adverse health effects, particularly the cardiovascular system. Most of these effects manifest after prolonged use, and occur primarily as a result of increases in heart rate, blood pressure, breathing rate, pulse, and respiratory rate .In a study of women who used anabolic steroids for 5 years, the increase in high-density lipoprotein cholesterol significantly (P = 0.003) improved the menopausal hormone therapy, but anabolic steroids had no significant effect on total cholesterol or LDL cholesterol .A major concern with weight gain is that it becomes irreversible. Over time, the body begins to lose and store fat in excess of what is needed for life, leading to weight gain in many cases . The increased level of fat in the body can accelerate aging processes by causing the formation of scurvy, the weakening of the intestinal lining, and increased incidence of gastrointestinal hemorrhages. As the body loses energy, the kidneys start to produce less acid to compensate. This weakens the barrier lining of the small intestine and makes it even more difficult for the digestion of food. This increases the risk of heart disease, pancreatitis, diabetes, and stroke . Although other studies point out that insulin resistance is a major factor in weight gain , the effects of diet and exercise have been less investigated. One large study of adults showed that anabolic steroids did not cause obesity . A recent study of a subset of patients who underwent weight loss and was followed for up to 3 years found that patients who started gaining weight (at least 5 percent of their average body weight) had a greater increase in liver enzymes than those who started to lose weight at lower weights .The adverse health effect of steroid use is not limited to the cardiovascular system, as it can lead to the development of cancer. However, there are more cases of bladder, breast, kidney, endocrine, and liver cancers that are associated with steroid use than those related to alcohol or smoking. The incidence of these malignancies, which usually occur in young, working men, is increasing. The primary cause of the increase in these types of cancers is the increasing use of anabolic steroids and the reduction in the use of tobacco cigarettes .A more serious risk of steroid use occurs when the user suffers from an overactive pituitary gland. There have been numerous reports in the media of men who developed an overactive pituitary gland asSimilar articles: